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Revista chilena de obstetricia y ginecología

versión On-line ISSN 0717-7526

Resumen

GONZALEZ CARVALLO, Cristián  y  CARVAJAL C, Jorge. L-arginina: suplemento nutricional sin beneficios demostrados en patologías del embarazo. Rev. chil. obstet. ginecol. [online]. 2013, vol.78, n.3, pp.179-186. ISSN 0717-7526.  http://dx.doi.org/10.4067/S0717-75262013000300003.

Objective: Critical analysis of randomized clinical trials to determine whether supplementation with L-arginine improves perinatal outcome in pregnant patients at risk or presenting conditions such as preterm labor, hypertensive disorders or intrauterine fetal growth restriction. Methods: We performed a literature search in Pubmed, Tripdatabase and multisearch in the Library System of the Pontifical Catholic University of Chile to further critical analysis of selected studies. Results: We selected 14 randomized trials, 4 of them are for studies of L-arginine in gestational hypertension, 5 studies of L-arginine in preeclampsia, one study of L-arginine in preterm labor, one study of L-arginine in chronic hypertension and 4 studies of L-arginine in intrauterine growth restriction. Only two of the studies were of good methodological quality, but one these studies analyzes an intermediate result that is not clinically relevant. The most promising result shows that the use of L-arginine associated with antioxidant vitamins significantly reduced the incidence of preeclampsia in women at risk (personal or family history of preeclampsia). Conclusions: Is not shown the effectiveness of antenatal supplementation with L-arginine to improve perinatal outcome in pregnant women at risk or with pathological conditions such as premature labor, hypertensive disorders and fetal growth restriction. More studies of good design are needed to allow definitive conclusions.

Palabras clave : L-arginine; preeclampsia; preterm delivery; fetal growth restriction; chronic hypertension; hypertensive disorders.

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