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Revista chilena de obstetricia y ginecología

versión On-line ISSN 0717-7526

Resumen

GALVEZ S, Daniela et al. Uso de agonista de GnRH para inducir ovulación en ciclos de hiperestimulación ovárica controlada: Experiencia de Clínica Monteblanco, Santiago, Chile. Rev. chil. obstet. ginecol. [online]. 2014, vol.79, n.1, pp.27-30. ISSN 0717-7526.  http://dx.doi.org/10.4067/S0717-75262014000100005.

Objective: To present the experience of the Reproductive Medicine Unit of Clinica Monteblanco inducing oocyte final maturation by GnRh analogue administration. Methods: We analysed all IVF/ICSI cases performed in 2012, in which final oocyte maturation was induced by administration of GnRH analogue (Lupron®). Controlled ovarian hyperstimulation was achieved bydaily rFSH (Puregon®) and highly purified urinary gonadotropin (Menopur®) administration. In order to prevent premature LH rise, on the 5th day of stimulation daily GnRH antagonist (Orgalutran®) was added. Final oocyte maturation was induced by the administration of 1.25 mg leuprolide acetate (Lupron®). Follicular aspiration was subsequently performed under ultrasound guidance. All embryos were vitrified and transferred in a subsequent cycle. Results: We registered 110 patients. The mean number of recovered oocytes was 21; the proportion of mature oocytes was 72%, and the fecundation rate reached was 64%. No case of severe ovarian hyperstimulation syndrome (OHSS) was recorded. Conclusions: In this cohort, the use of leuprolide acetate for induce final oocyte maturation demonstrated to be an efficient alternative to induce oocyte final maturation, while preventing OHSS.

Palabras clave : Ovarian hyperstimulation syndrome; ovulation induction; GnRH analogue.

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