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Revista chilena de obstetricia y ginecología

versión impresa ISSN 0048-766Xversión On-line ISSN 0717-7526

Resumen

REYNA-VILLASMIL, Eduardo et al. Utilidad diagnóstica de la relación neutrófilos/linfocitos en embarazadas con preeclampsia. Rev. chil. obstet. ginecol. [online]. 2018, vol.83, n.3, pp.257-265. ISSN 0048-766X.  http://dx.doi.org/10.4067/s0717-75262018000300257.

OBJECTIVE:

To establish the diagnostic utility of the neutrophil/lymphocyte ratio in pregnant women with preeclampsia.

METHODS:

A case-control study was conducted at the Central Hospital “Dr. Urquinaona”, Maracaibo, Venezuela. A total of 180 pregnant women were selected. We included 90 preeclamptic patients as a study group (group A) and a control group selected for having age and body mass index similar to the study group, which consisted of 90 healthy normotensive pregnant women (group B). The general characteristics, values of the neutrophil/lymphocyte ratio and diagnostic efficacy were determined.

RESULTS:

Patients in group A had significantly higher values of leukocytes and neutrophils compared to patients in group B (p < 0.05). On the other hand, patients in group A had lower lymphocyte values compared to patients in group B (p <0.001). Statistically significant differences were found in the neutrophil/lymphocyte ratio between patients in group A (4.0 +/- 1.3) compared with patients in group B (2.9 +/- 0.9, p <0.001). A cut-off value of the neutrophil/lymphocyte ratio of 3.4 showed a value under the curve of 0.96, sensitivity of 92.2%, specificity of 87.8%, positive predictive value of 88.3% and negative predictive value of 91.9%, with a diagnostic accuracy of 90.0%.

CONCLUSION:

The neutrophil/lymphocyte ratio is a useful tool in the diagnosis of preeclampsia, since the patients with the syndrome have significantly higher concentrations than the normotensive controls.

Palabras clave : Neutrophil/lymphocyte ratio; Preeclampsia; Diagnosis; Pregnancy.

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