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Revista chilena de obstetricia y ginecología

Print version ISSN 0048-766XOn-line version ISSN 0717-7526

Abstract

HERNANDEZ B., Olivia  and  GRUPO GESTACOVID et al. COVID-19 and pregnancy in Chile: preliminary report of the GESTACOVID multicenter study. Rev. chil. obstet. ginecol. [online]. 2020, vol.85, suppl.1, pp.S75-S89. ISSN 0048-766X.  http://dx.doi.org/10.4067/S0717-75262020000700011.

Introduction:

In Chile, effects of the SARS-CoV-2 infection in pregnant women are unknown. GESTACOVID is a multicenter collaborative study including pregnant women and those in the postpartum period (until 42 days) who have had COVID-19. The purpose of this study is to report our preliminary results describing the clinical impact of COVID-19 in pregnant women, the associated risk factors and perinatal results.

Methods:

Descriptive cohort study including 661 patients between April 7th and July 6th, 2020, in 23 hospitals. Demographical, comorbidities, clinical and diagnostic characteristics of COVID-19 disease and maternal and perinatal outcomes were analyzed.

Results:

Pregnant women with COVID-19 admitted to the hospital were more likely to have chronic hypertension [10% vs 3%; OR=3.1 (1.5–6.79); p=0,003] and diabetes type 1 and 2 [7% vs 2%; OR=3.2 (1.3–7.7); p=0.009] than those with outpatient management. A body mass index of >40 kg/mt2 was associated with two-fold higher risk of hospitalization [OR=2.4 (1.2–4.6); p=0.009]. Almost half of patients (54%) were delivered by cesarean section, and 8% of the medically indicated deliveries were due to COVID-19. So far, 38% of the patients are still pregnant. Among 316 newborns, there were 21 positive PCR tests (6.6%), mostly from asymptomatic mothers undergoing universal screening.

Conclusions:

Pregnant women with COVID-19 and comorbidities such as diabetes, chronic hypertension and morbid obesity need a close follow up and should be a matter for further research. Vertical transmission of COVID-19 should be thoroughly studied to define the mechanisms and type of infection involved.

Keywords : SARS-CoV-2; pandemic; viral infections; pregnancy; vertical transmission; atypical neumonia; coronavirus; respiratory distress syndrome.

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