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Revista chilena de neuro-psiquiatría

versión On-line ISSN 0717-9227


WULFF M, Cristian. Clozapine, neutropenia and prednisone test. Rev. chil. neuro-psiquiatr. [online]. 2007, vol.45, n.2, pp.114-119. ISSN 0717-9227.

Introduction: Clozapine is one of the most efficient atypical neuroleptics to treat resistant schizophrenias. In 0.5 to 0.8% of the patients can produce a serious complication -agranulocytosis-that is potentially mortal. To detect opportunely this problem the treatment is monitored by regular white blood count and absolute neutrophil count. Objective: Measure the central reserve of neutrophils by means of the administration of prednisone in patients that receive clozapine and that they present a recount of leukocytes < of 3.500 mm3 and/or of neutrophils < 2.000 mm3. Method: To 16 patients that present an or both conditions is administered prednisone 50 mgr. c/12 hrs oral during a day and the white blood count and absolute neutrophil count is repeated the morning of the following day. Results. The sixteen patients present an increase of the recount of neutrophils, average 5.863 mm3 + 2.656, maximum 13.501, minimum 2.667. The basal recount average was 1.589 mm3 + 244, maximum 1.975, minimum 1.095. Conclusions: Taking as reference the results of the administration of prednisona to healthy subjects in previous investigations, the central answer of the patients studied was considered satisfactory and in agreement to the protocol suggested by the medical hematologist continued with the habitual monitoring without subsequent complications

Palabras clave : neutropenia; clozapine; prednisone; prednisone test.

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