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vol.49 issue2Fernando Oyarzún, the idea of ethic person and vital materialismA bibliometric analysis of free submissions presented to the psychiatry section of the congresses of the Sociedad Chilena de Neurología, Psiquiatría y Neurocirugía, 2000-2009 author indexsubject indexarticles search
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Revista chilena de neuro-psiquiatría

On-line version ISSN 0717-9227

Abstract

SOLER, Bernardita  and  VON BERNHARDI, Rommy. Stem cells transplant: potentially useful mechanism for neurology. Rev. chil. neuro-psiquiatr. [online]. 2011, vol.49, n.2, pp.189-199. ISSN 0717-9227.  http://dx.doi.org/10.4067/S0717-92272011000200010.

Stem cells have a great potential for the treatment of presently incurable neurological diseases, including spinal trauma, cerebrovascular pathology, brain tumor and neurodegenerative processes, such as Parkinson and Alzheimer's disease, Huntington, multiple sclerosis and amyotrophic lateral sclerosis. Aims: To discuss the characteristics of the various stem cells types having been proposed for cell therapy, and the biological mechanisms responsible for their therapeutic effects. Report: Stem cells can be induced to differentiate into specialized cells such as neurons and glial cells, and they can influence the environment around them, both through the secretion of neurotrophic factors and immunomodulation of the host neuroimmune response. Furthermore, the understanding of the modulatory effect of stem cells could lead to the development of new therapeutic paradigms. Nevertheless, two important limitations of the field are that the ideal source for stem cells is not well defined yet and the mechanism of stem cell mediated functional improvement is not well understood. Conclusions: Research is currently focused on the biological mechanisms of stem cells therapy and the assessment of stem cell programming and delivery to the target regions. Furthermore, future research will increasingly target ways to enhance effectiveness of the stem cell therapy, including its combination with gene therapy. Regardless its enormous potentials, there are still many problems to be solved before clinical application of stem cell therapy can de used in neurological disease patients.

Keywords : Angiogenesis; Glia; Immunomodulation Neuroinflammation; Neurotrophic factor; Transdiferentiation.

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