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Revista chilena de neuro-psiquiatría

versão On-line ISSN 0717-9227


LEIVA R, Juan  e  PALESTINI Q, Mario. Copper and hippocampus neurophysiology. Rev. chil. neuro-psiquiatr. [online]. 2012, vol.50, n.3, pp.158-165. ISSN 0717-9227.

Copper is an oligoelement essential for various enzymatic processes both in pathology and in human physiology. Its excessive accumulation in the liver and brain, particularly in the basal ganglia drives to the pathological syndrome known as Wilson's disease, on the other hand, this metal absence in the newborn provokes brain and cerebellar degeneration, pathology recognized as Menkes' disease. Currently its role in Parkinson, Alzheimer and lateral amyotrophic sclerosis is discussed. Our studies in rats about the copper effects in the hippocampus excitability, long term potentiation (LTP) and learning have shown a suppressor action on LTP, without memory alteration nor on the animal learning in the Morris' aquatic maze, a physiological paradoxical result and in its clinical inference also.

Palavras-chave : Copper; hippocampus; neurophysiology.

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