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Revista chilena de neuro-psiquiatría

versión On-line ISSN 0717-9227

Resumen

VILLANUEVA-ESPARZA, Pablo Andrés. Is exposure to clozapine in the elderly adult associated with risk of leukopenia?. Rev. chil. neuro-psiquiatr. [online]. 2018, vol.56, n.1, pp.28-35. ISSN 0717-9227.  http://dx.doi.org/10.4067/s0717-92272018000100028.

Introduction:

Clozapine is an atypical antipsychotic used in refractory schizophrenia. It is the only antipsychotic that requires hematological control because the risk of agranulocytosis is potentially fatal, limiting its use. It is not clear if this risk increases in older adults: some studies have shown that clozapine-induced neutropenia is moreprevalent in old age, while others have not shown such an increase.

Objetive:

Quantify the risk of leukopenia in elderly patients who are clozapine users.

Material and Method:

A case-control study was conducted in elderly users of clozapine from HHHA during theyears 2001-2016. The clozapineprogram cards, the HHHA digital statistical databases and the National Clozapine Program were reviewed. The number of users with adverse hematological events and the age of the patients were quantified to differentiate them in patients older patients (exposed) or under 60 years old (not exposed), and if these had (cases) or not, alarm events (controls). A stratified analysis was performed.

Results:

The use of clozapine in older adults was protective for the development of leukopenia.

Palabras clave : Aged; Clozapine; Leucopenia.

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