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Revista chilena de radiología

On-line version ISSN 0717-9308


ORTEGA, Ximena et al. Variability in magnetic resonance quantification of muscle fat fraction using Dixon's technique. Rev. chil. radiol. [online]. 2016, vol.22, n.4, pp.149-157. ISSN 0717-9308.

Abstract. Muscle MRI has emerged as a valuable tool in the diagnosis of neuromuscular-disorders. The Dixon fat-water separation technique allows objective intra-muscular fat quantification. There are few reports concerning measurement standardisation with Dixon technique. The objective of this study was to evaluate the variability in fat quantification using Dixon's technique in a cohort of patients with congenital myopathies, by analysing intra-segment, intra-muscle, and inter-muscle variability of 60 muscles in each patient. Whole body MRI was performed on 31 patients, 23 with congenital myopathies and 8 healthy controls, aged between 10 months and 35 years old, from January 2014 to June 2016. The mean fat-fraction in healthy patients was around 5%, with less than 2% intra-muscle variability. An intra-muscle variability between 3.1-7.8% was estimated in patients with congenital myopathies. It may be concluded that there is high intra- and inter-muscle fat-fraction variability among patients with congenital myopathies, and this is an observation that should be incorporated in the analysis of fat replacement.

Keywords : Magnetic resonance imagining; Muscle; Whole body; Dixon; Fat fraction; Congenital myopathies.

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