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Revista chilena de radiología

versión On-line ISSN 0717-9308


LADRON DE GUEVARA H., David et al. Solitary lung nodule: is volumetric doubling time assessment really useful for differentiating a malignant from a benign lesion?. Rev. chil. radiol. [online]. 2020, vol.26, n.4, pp.133-140. ISSN 0717-9308.

Aim: To establish the diagnostic accuracy of doubling time (DT) assessment in evaluation of solid lung nodules (LN). Method: Computed Tomography (CT) of patients referred for PN were reviewed, selecting those with an available CT for comparingcomparison. We included LN with histologic confirmationconfirmed by histology only. LN histologically proved as metastases were excluded. DT were calculated both by methodology 2D and 3D methods. Results: Seventy oneSeventy-one LN in 60 patients (median 68 y, 45-92 y,59% men) were studied, 63 of them malignant (corresponding a primaries primary lung neoplasms), and 8 were benign. There were not no significant differences in ROC curves among DT calculated by 2D or 3D methodology. Sensitivity, specificity and negative predictive value were 63,5%, 62,5% and 17,9% for DT between 40-400 days; and 80,9%, 37,5% and 20,0% for DT between 20-600 days. Conclusion: DT assessment has limited utility for rule outruling out malignant nature of a solid LN.

Palabras clave : Doubling time; Imaging; Lung cancer; Multidetector Computed Tomography; Solitary pulmonary nodule; Three-Dimensional.

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