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International Journal of Morphology

On-line version ISSN 0717-9502

Abstract

LARA, Cristina Picoli et al. FFECTS OF CADMIUM ON THE RAT JUGAL MUCOSA DURING LACTATION. MORPHOLOGICAL AND HISTOMETRICAL STUDY. Int. J. Morphol. [online]. 2003, vol.21, n.3, pp.191-198. ISSN 0717-9502.  http://dx.doi.org/10.4067/S0717-95022003000300002.

Cadmiun in the air, drinking water and food has the potential to affect the health of people, mainly those who live in highly industrialized regions. Cadmium affects placental functions, can cross the trophoblastic barrier and directly disturb the fetal development. It is also excreted into milk. The organism is particularly susceptible to cadmium exposure at perinatal period. The effect on rat oral epithelium (upper vestible and floor of the mouth) after a continuous exposure to drinking water containing low level of cadmium during lactation was studied. Female rats received drinking water containing 300 mg/l CdCl2 ad libitum during the whole lactation. Control animals received a similar volume of water without cadmium. Lactant rats (21 day-old) were killed by letal dosis of anesthetic. The head were separated, fixed in alfac solution for 24 h. Palate and jaw regions were serially sectioned in frontal plane, at level of first molars, and the 6 µm thick sections were stained with hematoxylin and eosin. Nuclear epithelium parameters were estimated, as web as cytoplasm and cell volume, nucleus/cytoplasm ration, number and surface density, and epithelial thickness. Mean body weignt was 34.86 g for the control group and 18.56 g for the treated group. Histologically, the epithelium was thinner, with more numerous and smaller cells. In this experiment, cadmium induced epithelial atrophy, indicating a direct action in oral mucosae cells, besides restricted development in pups

Keywords : Oral mucosa; Cadmium; Lactation; Rat; Histopathology; Morphometry.

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