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vol.22 número2EFECTOS DEL CICLAMATO DE SODIO EN EL RIÑON FETAL DE RATAS: ESTUDIO MORFOMÉTRICOASOCIACIÓN ENTRE LA PÉRDIDA DEL CROMOSOMA X EN MUJERES DE EDAD AVANZADA Y EL POLIMORFISMO DE LA APOLIPOPROTEÍNA A-IV: 360 GLN/HIS índice de autoresíndice de materiabúsqueda de artículos
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International Journal of Morphology

versión On-line ISSN 0717-9502

Resumen

SIESSERE, Selma et al. MORPHOLOGICAL AND MORPHOMETRIC ALTERATIONS INDUCED BY VALPROIC ACID ON RAT FETUSES' MECKEL'S CARTILAGE, LINGUAL MUSCULATURE, AND SUBMANDIBULAR GLAND. Int. J. Morphol. [online]. 2004, vol.22, n.2, pp.133-137. ISSN 0717-9502.  http://dx.doi.org/10.4067/S0717-95022004000200006.

Valproic acid, an antiepileptic drug, is a well-known teratogenic agent; its main target organ is the neural tube, though organ malformations have also been described. The aim of the present work was to analyze the effects of valproic acid on embryo/fetal oral structures: Meckel's cartilage, muscles of the tongue, and submandibular gland. Rats received a intraperitoneal injected of Valproic acid (300mg/Kg) on the 10th day of their gestation. Females were sacrificed on day 20 post coitus, and fetuses were examined. No gross malformations were observed. The following morphological alterations were observed: lower body and placental weight; shorter umbilical cord length; submandibular gland parenchyma less differentiated with larger cellular cord and terminal buds, and increased nuclear volume; lingual muscles fibers disorganized and of smaller size, and smaller nuclear volume; rudimentary Meckel's cartilage with small chondrocytes and more abundant matrix. These data suggest that alterations in oral tissue, induced by valproic acid, result from a direct effect of the drug on tissues causing a delayed differentiation

Palabras clave : Valproic acid; Rat; Meckel's cartilage; Lingual musculature; Submandibular gland.

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