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International Journal of Morphology

On-line version ISSN 0717-9502


VASCONCELLOS, A.; VILLAGRAN, E.; ASTUDILLO, M.  and  CABEZAS, P. Immunocytochemistry Study of Estrogen Receiver Alfa Fraction and Progesterone in Endometrial Polyps. Int. J. Morphol. [online]. 2005, vol.23, n.2, pp.123-127. ISSN 0717-9502.

The endometrial polyps are a frequent cause of anormal bleeding and in same cases responsible of sterility. Their pathogenesis is poorly understand. They are masses sessiles or pedunculated that protrudes into the endometrial cavity.Thehistologic pattern resembles proliferative endometrium with fibrous stroma and estrogenic glands that can show irregularity and occasionally hyperplasia. The hormonal action is fundamentalfor the development of normal and pathologic endometrium. Quantitativealterations of the estrogen and progesterone receptors contributes to the pathogenesis of endometrial polyps. They could arise from localized overexpression of estrogen receptors (ER), reduced expression of progesterone receptors (PR) or both. This study was undertaken to evaluate with inmunocytochemistry the presence of estrogen receptors alfa and progesterone receptors in endometrial polyps of 9 patients. The intensity of staining was record on a scale high, moderate and weak or negative and compared with the staining in normal endometrium. High levels of ER a was seen in glandular epithelium, stroma and endothelial cells of capillaries that are surrounding the glands. The PR are negatives or very weak in stoma and glands. We conclude that endometrial polyps have a alterate distribution of the receptors with and increase number of stromal and glandular epitheliumlER alfa and a decrease of PRdetaching the large number of ER a in perivascular cells and in endotelial cells

Keywords : polyps; Estrogen receptors; Progesterone receptors.

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