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International Journal of Morphology

On-line version ISSN 0717-9502


MONTENEGRO, María Angélica  and  ROJAS, Mariana. Molecular Basis on the Face and Palate Development. Int. J. Morphol. [online]. 2005, vol.23, n.2, pp.185-194. ISSN 0717-9502.

In mammals, the adhesion and fusion of the facial and palatal shelves are essential mechanisms in the development of the primary and secondary palate. Failure of any of these processes leads to the formation of cleft lip and palate. In both cases, the opposing shelves adhere to each other by desmosomes to form an epithelial seam which disappears by epithelial-mesenchymal transformation. Apoptosis occurs only in the periderm. In the palate, these processes are regulated by TGFß-3, but in the face this growth factor is not present in maxilar and nasal shelves and in lip formation would act other factors, such as Shh and BMP that have been shown to be involved in avian lip confluence

Keywords : Mouse palate; Avian lip; TGFß-3; Shh; Epithelial-mesenchymal transformation; Epithelial seam.

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