SciELO - Scientific Electronic Library Online

vol.24 número2Osificación Competa del Ligamento Escapular Superior en un Hombre Adulto de la IndiaDescripción Histológica de los Diferentes Segmentos del Aparato Digestivo de Avestruz (Struthio camelus var. domesticus) índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados




Links relacionados


International Journal of Morphology

versión On-line ISSN 0717-9502


SILVA, Rogério Ferreira da et al. Action of Trivalent Chromium on Rat Liver Structure. Histometric and Haematological Studies. Int. J. Morphol. [online]. 2006, vol.24, n.2, pp.197-203. ISSN 0717-9502.

The trace mineral trivalent chromium (Cr3+) is an essential nutrient involved in the regulation of carbohydrate, lipid and protein metabolism via an enhancement of insulin action. The present work had as objective to characterize histopathologically and histometrically the hepatic alterations of female Wistar rats, determined by the chromium III administration in drinking water. Adult rats received ration and drinking water ad libitum containing 300 or 500 mg/l chromium III during 4 months. Control animals received only water and ration. All animals were sacrificed by lethal dose of anesthetic. Samples of liver were fixed in 10% formalin for 24 h. Tissues for microscopical pathology were processed using standard procedures. Paraffin sections prepared at 6 µm were stained with haematoxylin and eosin and PAS. Besides the histopathological exam, histometrical techniques were used. The blood was collected and processed for hematological study. Histopathological analysis revealed periportal, midzonal and pericentrilobular zones with parenchyma cells with varying degrees of vacuolation. Many hepatocytes are ballooned and the nuclei were in lysis. The centrilobular vein was dilated and congested. Dilated sinusoids containing erythrocytes were observed. The portal area showed fibrosis, biliar duct proliferation with small cells. Histometric study showed increased cytoplasm and cell volumes, and small values for number of hepatocytes per mm3. Lymphopenia was observed in 500 mg/l Cr3+/l treated animals. These results indicate that the chromium III has a direct participation in liver structures alterations

Palabras clave : Liver; Rat; Chromium; Morphometry; Hematology.

        · resumen en Español     · texto en Inglés     · Inglés ( pdf )


Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons