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International Journal of Morphology

On-line version ISSN 0717-9502

Abstract

PEREIRA, Marli Aparecida dos Santos et al. Morphological and Quantitative Analyses of the NADH-d Myenteric Neurons of the Jejunum of Rats Submitted to Experimental Chronic Alcoholism . Int. J. Morphol. [online]. 2006, vol.24, n.3, pp.391-398. ISSN 0717-9502.  http://dx.doi.org/10.4067/S0717-95022006000400016.

The objective of our work was to verify, during an experimental period of 210 days, the possible effects of the ethanol on the morphology and density of the NADH-diaforase myenteric neurons in the jejunum of alcoholic rats. We used 10 animals (Rattus norvegicus) separated in 2 groups: the controls (n=5), that received a normal proteic diet (22%) and water ad libitum; the alcoholic, that received NUVILAB normal proteic chow (22%) and sugar cane brandy diluted at 30 Gay Lussac (30 v/v). The jejunum segment was collected and submitted to the histochemical technique to stain the nervous cells and, then, to the elaboration of membrane whole mounts. The observation through light microscopy showed that there are no expressive morphologic differences between the ganglia of neurons of the control and alcoholic rats. The counting of neurons, carried out in 40 microscopic fields (8.96µm2) in the control group, at the mesenteric and antimesenteric regions, found 1,131 and 693 neurons respectively, while, the alcoholic group found 1,229 and 860 neurons. The significant increase in the number of neurons in the mesenteric region, in the alcoholic rats, is due to the smaller physical growth of those animals when compared to the controls. The ethanol caused malnutrition and consequently the alcoholic rats showed a larger neuronal density due to its smaller dispersion

Keywords : Jejunum; Myenteric neurons; Rats; Alcoholism.

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