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International Journal of Morphology

On-line version ISSN 0717-9502


ISSA, Joao Paulo Mardegan et al. Biochemical Analysis by Calcium Determination on the Newly Formed Bone in Critical Bone Defects Submitted to Different Treatments: A Pilot Study. Int. J. Morphol. [online]. 2007, vol.25, n.3, pp.511-518. ISSN 0717-9502.

The aim of this study was to evaluate the calcium dosage of the newly formed bone, in critical bone defects created on the calvarial tissue and filled by different substances, in male Wistar rats. A cylindrical critical bone defect (6x2mm) was created in the posterior portion, left side, on the calvarial bone in nine animals and filled with: animals' coagulum, monoolein gel, poloxamer gel, monoolein gel + 1µg rhBMP-2, monoolein gel + 3µg rhBMP-2, monoolein gel + 7µg rhBMP-2, poloxamer gel + 1µg rhBMP-2, poloxamer gel + 3µg rhBMP-2, poloxamer gel + 7µg rhBMP-2. The results of this study showed a positive correlation between the calcium dosage analysis and the newly formed bone

Keywords : Bone repair; Biomaterials; rhBMP-2; Carriers; Calcium.

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