Abstract

OLUYEMI, Kayode A; OKWUONU, Uche C; BAXTER, D. Grillo  and  OYESOLA, Tolulope, O. Toxic Effects of Methanolic Extract of Aspilia africana Leaf on the Estrous Cycle and Uterine Tissues of Wistar Rats. Int. J. Morphol. [online]. 2007, vol.25, n.3, pp.609-614. ISSN 0717-9502.  http://dx.doi.org/10.4067/S0717-95022007000300023.

Effects of graded dosages of methanolic extract of Aspilia Africana were examined on the estrous cycle, uterine weights and histology to determine its effects on the reproductive functions of 25 cyclic female rats. The rats were randomized into five groups A, B, C, D, and E. They were given Omg/kg body weight, 150 mg/kg body weight, 200 mg/kg body weight, 250 mg/kg body weight, and 300 mg/kg body weight, respectively. The effect on the estrous cycle was determined by vaginal lavage while routine histological preparations were done with haematoxylin-eosin stains. All values were statistically compared at appropriate confidence intervals. Estrous cycles were significantly reduced in a dose-dependent manner and histology revealed a dose-dependent toxicity

Keywords : Aspilia africana; Estrous; Uterine weight; Histology; Reproductive functions.

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