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International Journal of Morphology

versión On-line ISSN 0717-9502


JIMENEZ VENEGAS, Leonella; QUILODRAN PEREDO, Javier; MIRANDA OLIVARES, Juan Pablo  y  RODRIGUEZ BUSTOS, Héctor. Effect of a Single Doses Intraperitoneal of Cypermethrin in Brain Somatosensory Area of Mice CF-1. Int. J. Morphol. [online]. 2008, vol.26, n.1, pp.19-26. ISSN 0717-9502.

The cypermethrin is a pesticide widely used in agriculture and public health. Their histopathological effects at central nervous system level, little have been studied, even though has demonstrated cases of poisoning in humans with important neurological commitment. The aim of this work is to know the effects a intraperitoneal single dose of cypermethrin on neuronal morphology of somatosensory cortex (superficial and deep laminae) of mice CF-1. 35 mice were separated in three groups: control (n=5), control vehicle (n=15) and experimental (n=15); the two last sacrificed groups 1, 8, 18, 26 and 35 days, three animals per group. The brain were removed, fixed, and process with routine technique, for a morphometric analysis. Statistical analysis with Kruskal Wallís test. We demonstrated corresponding morphologic alterations until death neuronal, in all studied laminae, at the different time intervals.

Palabras clave : Sensory cortex; Apoptosis; Cipermethrin; Neurotoxicity.

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