SciELO - Scientific Electronic Library Online

vol.26 número1Estudio de Dominancia de la Arteria Sinoatrial Nodal en Corazones Humanos BrasileñosComposición de los Tipos de Fibras del Músculo Semitendinoso de Ratas Wistar y los Efectos del Entrenamiento Intermitente en su Hipertrofia índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados




Links relacionados


International Journal of Morphology

versión On-line ISSN 0717-9502


SILVA JUNIOR, Valdemiro Amaro da et al. Neonatal Administration of Fluoxetine Decreased Final Sertoli Cell Number in Wistar Rats. Int. J. Morphol. [online]. 2008, vol.26, n.1, pp.51-62. ISSN 0717-9502.

The aim of the present study was to test the hypothesis that the application of fluoxetine ­ a highly selective serotonin reuptake inhibitor (SSRI) ­ in rats during the suckling period induces changes in testicular development. Groups of newborn male rats were randomly assigned with different doses of fluoxetine 24 hours after birth. Each litter stayed with its respective mother during 21 days. Body weight (BW) was measured daily from the 1st -21st day to calculate daily doses of fluoxetine. 5 mg (T1), 10 mg (T2) 20 mg (T3) or deionized water, were injected intraperitoneally. On the 21st day, animals were heparinized, anesthetized and blood was collected by cardiac puncture to determine by radioimmunoassay the follicle stimulating hormone (FSH) levels. Testis were removed, weighed, and processed for morphometric analysis. Fluoxetine groups presented decreased body and testicular weight when compared with the control group on the 21st day. Our findings show that the manipulation of the serotoninergic system with fluoxetine during the critical period of testicular development alters the Sertoli cell population and all testicular parameters related to this cell.

Palabras clave : Fluoxetine; Testis development; Sertoli cells; Wistar rats.

        · resumen en Español     · texto en Inglés     · Inglés ( pdf )


Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons