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International Journal of Morphology

On-line version ISSN 0717-9502

Abstract

PRIETO, Ruth; MATAMALA, Fernando  and  ROJAS, Mariana. Immunological Distribution of the Placental Lactogene and IGF-1 Receptor on Free-chorionic Villi of the Newborns Small for Gestational Age Placentae. Int. J. Morphol. [online]. 2008, vol.26, n.4, pp.1029-1033. ISSN 0717-9502.  http://dx.doi.org/10.4067/S0717-95022008000400039.

The aim of this study was observe differences in the immunological distribution of the placental lactogene and IGF-1 receptor on free-chorionic villi, between studied groups and to relate the neonatal diagnosis of PEG with morphometric and immunohystochemical characteristics of the placenta. A total of, twelve placentas from AEG newborn and twelve from PEG newborn were obtained from the Maternity Ward of Temuco, Chile. H&E, Alcian blue and Masson's trichromic stains, as well as Hematoxilyn-PAS. In the immunoperoxidase technique, were used: 1) placental lactogen (polyclonal, dilution 1:200, NCL-PLP, Novocastra) 2) Insuline-1 like growth factor (monoclonal, dilution 1:200, NCL-GHR, No vocastra). Differences between PEG and AEG placentae in the immnunostaing for placental lactogen and IGF-1 receptor in the sincitial throphoblast were not observed.

Keywords : IGF-1 receptor; Free-chorionic villi; Newborns; Gestational age.

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