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International Journal of Morphology

On-line version ISSN 0717-9502

Abstract

ZANONI, Jacqueline Nelisis; PEREIRA, Priscila Goncalves Cardoso  and  DOS SANTOS PEREIRA, Marli Aparecida. Analysis of Myenteric Neurons of the Cecum of Diabetic Rats After Supplementation with Ascorbic Acid. Int. J. Morphol. [online]. 2009, vol.27, n.2, pp.387-392. ISSN 0717-9502.  http://dx.doi.org/10.4067/S0717-95022009000200013.

The objective of this work was to investigate the neuroprotective action of the ascorbic acid over the myenteric neurons in the cecum of Wistar rats, four months after induction of the diabetes mellitus experimental with streptozotocin. Three groups with five rats each were used: C- controls, D- diabetic, DA- diabetic treated with ascorbic acid. For evidentiation of the myenteric neurons was carried out to Giemsa's technique. Were evaluated the areas of cell bodies of 500 neurons in each group studied. The quantitative analysis was carried out in an area of 16.6 mm2 in each cecum studied. In the animals diabetic observed elevation of the glycemia and glycated hemoglobin. The supplementation with ascorbic acid was effective under the myenteric neurons of the cecum of diabetics rays, since was presented the effect neuroprotective and neurotrofic.

Keywords : Ascorbic acid; Diabetes mellitus; Oxidative stress; Cecum; Streptozotocin.

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