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International Journal of Morphology

versión On-line ISSN 0717-9502

Resumen

PEREIRA, Marli Aparecida dos Santos; LIBERATI, Ana Paula; SOUZA, Ivan Domicio da Silva  y  ZANONI, Jacqueline Nelisis. Density and Morphometry of Overall Myenteric Neurons Population from the Duodenum of Diabetic Rats (Rattus norvegicus) under Ascorbic Acid Supplementation. Int. J. Morphol. [online]. 2009, vol.27, n.2, pp.413-418. ISSN 0717-9502.  http://dx.doi.org/10.4067/S0717-95022009000200017.

The objective of this work was to evaluate the overall myenteric neurons population from the duodenum of adult streptozotocin-induced diabetic rats supplemented with ascorbic acid (AA), a potent antioxidant. Fifteen 90-day-old rats were divided in groups: control (C), diabetic (D), diabetic treated with ascorbic acid (DA). After 120 days of experimental period duodenums were resected and processed as whole-mount preparations according to Giemsa's technique, which allowed us to evaluate neuronal density in an area of 8.96 mm2 and measure the area of 500 neuronal cell bodies per group. It was observed a 32.55% reduction in neuronal density of group D when compared to group C (p<0.05). The density of spared neurons in group DA, in relation to group D, was not statistically different in this experimental model. No significant differences were found in neuronal areas when groups C and D or group D and DA were compared (p>0.05). These results lead us to conclude that the density of overall myenteric neurons population from the duodenum was reduced in diabetic rats (D), when compared to its control (C); and that diabetic rats supplemented with AA (DA) did not have their neuronal density preserved when compared to diabetic animals (D).

Palabras clave : Ascorbic acid; Diabetes mellitus; Duodenum; Oxidative stress.

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