SciELO - Scientific Electronic Library Online

 
vol.27 issue4Evaluation of Dental Eruption of Third Molars in the Length of MandibleAortic Bifurcation Levels in Chilean Individuals author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


International Journal of Morphology

On-line version ISSN 0717-9502

Abstract

MONTIEL-EULEFI, E; SANCHEZ, R; ROJAS, M  and  BUSTOS-OBREGON, E. Epiblast Embryo Stem Cells Give Origin to Adult Pluripotent Cell Populations: Primordial Germ Cell, Pericytic and Haematopoyetic Stem Cells. A Review. Int. J. Morphol. [online]. 2009, vol.27, n.4, pp.1325-1333. ISSN 0717-9502.  http://dx.doi.org/10.4067/S0717-95022009000400056.

Adult stem cells are great promise to the future of regenerative therapy, and understanding of its embryonic origin permit the discrimination of stem cell sources. Embryonic stem cells derived from inner cell mass of blastocyst originate the primordial germ cells, and pericyte stem cell associated to vessels endothelium in yolk sac. Currently, it is being proposed that embryonic primordial germ cell could originate hematopoietic stem cells based on the detection of germ cell markers (SSEA-1/TEC-1, Oct-4 and Nanog) in stem cell harvested from fetal liver and bone marrow. However, different experimental evidence points at two separate differentiation routes toward primordial germ cells, and hematopoietic stem cell with the same embryonic origin. The expression of undifferentiated stem cell markers in umbilical cord and placental vessels, such CD34, CXCR4, c-kit and OCT4 demonstrates the intimate relation between pericyte stem cells, endothelium, haematopoiesis, and primordial germ cells, which all originate from embryonic stem cell from the inner cell mass epiblast.

Keywords : Stem cell origin; Primordial gem cell; Perycitic stem cell; Haemangioblast.

        · abstract in Spanish     · text in English     · English ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License