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International Journal of Morphology

versão On-line ISSN 0717-9502

Resumo

GUZMAN, Neftalí et al. Prothrombotic Variant C677T at the Methylenetetrahydrofolate Reductase Gene is a Molecular Biomarker of Implantation Failure in Chilean Women Undergoing Assisted Reproductive Protocols. Int. J. Morphol. [online]. 2010, vol.28, n.1, pp.65-69. ISSN 0717-9502.  http://dx.doi.org/10.4067/S0717-95022010000100008.

Implantation failures are considered an important cause of infertility in women undergoing assisted reproductive protocols. Recent evidence suggests that the presence of prothrombotic variants is associated with obstetric defects and reproductive failure. However, results between several populations are contradictory. According this evidence, we evaluated the potential association between prothrombotic variants and implantation failure susceptibility in Chilean women undergoing Assisted Reproductive protocols. 180 women, 80 patients undergoing assisted reproductive protocols and 100 controls were included in this study. Molecular genotyping of prothrombotic variants in candidate genes was realized by PCR-RFLP. We observed one patient heterozygote for factor V G1691A variant, and total absence to prothrombin G20210A polymorphism in patients and controls. Genotype distribution and allelic frequencies of MTHFR C677T polymorphism were significantly different between patients and controls (p<0.05). Odss Ratio for implantation failure associated to homozygote genotype was 2.78 (95% IC 1.147 ­ 6.755; p= 0.0199). In summary, our data suggest that the MTHFR C677T polymorphism constituted a molecular biomarker of implantation failure susceptibility in Chilean population.

Palavras-chave : Infertility; Implantation failure; Biomarker.

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