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International Journal of Morphology

versión On-line ISSN 0717-9502


GHADERI, Reza; AFSHAR, Mohammad; AKHBARIE, Hadi  y  GOLALIPOUR, Mohammad Jafar. Comparison of the Efficacy of Honey and Animal Oil in Accelerating Healing of Full Thickness Wound of mice skin. Int. J. Morphol. [online]. 2010, vol.28, n.1, pp.193-198. ISSN 0717-9502.

There are some medications and procedures that can be used to accelerate the healing of skin wounds. Some studies have demonstrated improvement of burn wound healing with honey treatment. In other hand, based on traditional medicine have improved wound healing with animal oil. This study was done to compare the efficacy of animal oil and honey in accelerating healing of full thickness wound of skin in mice. In this experimental study 36 male NMRI mice were subjected to full-thickness skin wounds under general anesthesia. Animals were randomly allocated to receive either single daily applications of placebo, animal oil and honey (n=12 for each group) respectively. On 4th, 7th and 10th days, four mice from each group were sacrificed using an overdose of anesthetic. Macroscopic and Microscopic characteristic of wounds were studied pathologically and histologically. The findings of this study showed that formation of granulation tissue, density and activation of fibroblasts, keratinization in surface of wound and thickness of basement membrane and epidermis in Honey treatment group was more than animal oil group. Honey more than animal oil decreased inflammation, edema and dehiscence of wound in mice. The wound healing rate in honey group was higher than in animal oil group (p<0.05). This study showed that honey more than animal oil accelerates healing of full thickness wound of skin in mice.

Palabras clave : Honey; Animal oil; Wound healing; Skin; Mice.

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