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International Journal of Morphology

On-line version ISSN 0717-9502

Abstract

BRIONES S, Flavio; CACERES D, Tamara  and  JARPA F, Marcia. Detection b-Amiloid, Hyperphosphorylate TAU Protein and Ubiquitin for Technique the Immunohistochemistry in Brains in Dogs over 10 Years. Int. J. Morphol. [online]. 2010, vol.28, n.4, pp.1255-1261. ISSN 0717-9502.  http://dx.doi.org/10.4067/S0717-95022010000400043.

The interest in the study of the process of cerebral aging and the changes in the behaviour related to age in geriatric canine and feline has increased in the last decade (Mentzel, 2005a; Ingram & Williams, 2010). The alterations of the canine behaviour that respond to physiopathological changes related to the age and which involve different conducts and cognitive spheres are included under the denomination of Canine Cognitive Dysfunction Syndrome (CDS) called canine Alzheimer, considering the cerebral and histopathologic behavioural similarities. In the present study the geriatric patients displayed the same abnormal protein deposits present in Alzheimer disease, such as senile plaques ubiquitinate bodies and the amyloid angiopathy. However they did not display the balls of neurofibrillary tangles which are characteristic of the disease. The only practical tools of evaluation in clinic for this pathology are the surveys and forms related to behavioural aspects. In addition there are post mortem exams such as those in inmunohistochemistry, that allow an effective identification of abnormal elements present in the neuropathology. In this study the monoclonal antibodies were used anti-b-amyloid, anti-protein tau and anti-ubiquitin in samples of brains in dogs over 10 years of age. The canine model constitutes an indispensable meaning for the study of the neurodegeneration processes because it has allowed an approach to the theory of the problem from a new perspective (Dimakopoulos & Mayer, 2002).

Keywords : Cognitive; Inmunohistochemistry; Amyloid; TAU protein; Ubiquitin.

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