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vol.28 issue4Histomorphometric Changes in the Testes and Epididymis of Wistar Strain Albino Rats Following Fourteen Days Oral Administration of Therapeutic Doses of Some AntibioticsInnervation of the Fibularis Longus and Brevis Muscles in Chilean Individuals: Anatomic and Biometric Study author indexsubject indexarticles search
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International Journal of Morphology

On-line version ISSN 0717-9502

Abstract

ASSIS, Thiago de Oliveira; ARAUJO FILHO, José Candido de  and  MAIA, Maria Bernadete de Sousa. Effects of Fetal Programming in the Inflammatory Response in Wistar Rats: A Systematic Review. Int. J. Morphol. [online]. 2010, vol.28, n.4, pp.1289-1294. ISSN 0717-9502.  http://dx.doi.org/10.4067/S0717-95022010000400048.

The aim of this study was to review the literature on the effects of fetal programming in the inflammatory response in Wistar rats. A search was performed in the following databases: PubMed, MEDLINE, PUBMED, SCIENCE DIRECT, SCOPUS, LILACS, SpringerLink. The main search terms were malnutrition and inflammation in Portuguese and in English. Original articles were included involving albino rats and review articles were excluded involving humans or animals other than rats. Articles that were related to malnutrition which was not intrauterine and did not involve the concept of fetal programming were also excluded.Those items found in more than one database were counted only once. Sixteen articles were found in PUBMED, 16 in SCOPUS, 4 in MEDLINE, 341 in SCIENCE DIRECT, 8 in SciELO, 1 in LILACS and 77 in SPRINGERLINK totalling 463 articles from which 4 were selected for analysis after applying inclusion and exclusion criteria. Fetal programming seems to interfere with the inflammatory response in the adult offspring of Wistar rats, but its mechanisms remain uncertain.

Keywords : Fetal Programming; Inflammation; Wistar Rats; Systematic review.

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