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International Journal of Morphology

On-line version ISSN 0717-9502


GONZALEZ JIMENEZ, Emilio; ALVAREZ FERRE, Judit  and  AGUILAR CORDERO, María José. Mandibular and Maxilar Osteonecrosis Secondary to Bisphosphonates: Introduction of Three New Cases. Int. J. Morphol. [online]. 2011, vol.29, n.3, pp.1022-1027. ISSN 0717-9502.

The use of bisphosphonates is now particularly important in the therapeutic management of various pathologies, as an integral part of standard therapy. However, in an almost parallel form, a large number of cases have been documented in which the patient following treatment with bisphosphonates, developed a vascular necrosis event in the maxillary and/or mandibular region. This is an event of complex approach which tends to compromise and undermine the quality of life for our patients. However the possible occurrence of this complication should not on the other hand, imply misgivings about their use in therapy, but rather constitute an event to be monitored during the time of therapy.The aim of this paper is to advise about possible complications in patients receiving bisphosphonate therapy through literature review and the presentation of these three new clinical cases.

Keywords : Bisphosphonate; Osteonecrosis; Cancer.

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