SciELO - Scientific Electronic Library Online

 
vol.30 issue2Anthropometric Comparison between Mandibles from Uruguayan and Brazilian PopulationsThe Behavior of Demineralized Bone Matrix (DBM) in Post-Extraction Sockets author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


International Journal of Morphology

On-line version ISSN 0717-9502

Abstract

JAHANSHAHI, M; AZAMI, N. S  and  NICKMAHZAR, E. Effect of Scopolamine-based Amnesia on the Number of Astrocytes in the Rat's Hippocampus. Int. J. Morphol. [online]. 2012, vol.30, n.2, pp.388-393. ISSN 0717-9502.  http://dx.doi.org/10.4067/S0717-95022012000200004.

As neuron­astrocyte interactions play a crucial role in the adult brain, it is thought that astrocytes support learning and memory through specific mechanisms. In this study, the effect of scopolamine based amnesia on the number of astrocytes in rats' hippocampus was studied. Adult male albino Wistar rats were bilaterally cannulated into the CA1 region and animals received saline or different doses of scopolamine (0.5, 1 and 2 mg/ rat, intra - CA1), immediately after training. Then all the rats were sacrificed and coronal sections were taken from the dorsal hippocampal formation of the right cerebral hemispheres and stained with PTAH. The area densities of the astrocytes in dentate gyrus were measured and compared in the all groups (p < 0.05). Data showed that post-training scopolamine (0.5, 1 and 2 µg/rat, intra-CA1) dose-dependently reduced the step-through latency in the inhibitory avoidance task, showing scopolamine-induced amnesia. Also we found different response of astrocytes in different subfields of hippocampal formation. In dentate gyrus the number of astrocytes was increased, but in other areas scopolamine can decreased the density of astrocytes. We concluded that scopolamine can cause amnesia and this phenomenon can have an effect on astrocyte numbers in the rats hippocampal formation.

Keywords : Scopolamine; Amnesia; Astrocyte; Hippocampus; Rat.

        · abstract in Spanish     · text in English     · English ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License