SciELO - Scientific Electronic Library Online

 
vol.30 issue4Co-culture of Mouse Two-cell Embryos on Human Endometrial Stromal Cells in Proliferative and Secretory PhasesCommentary: Is the Evidence for Localization of Nephrin on the Slit Diaphragm Rigid? author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


International Journal of Morphology

On-line version ISSN 0717-9502

Abstract

MUNOZ, L  and  CONCHA, M. L. Stem Cells in Development and the Perspectives of Cellular Reprogramming for Regeneration. Int. J. Morphol. [online]. 2012, vol.30, n.4, pp.1343-1347. ISSN 0717-9502.  http://dx.doi.org/10.4067/S0717-95022012000400015.

Multicellular organisms develop from one cell: the zygote. During ontogeny, cells derived from the zygote display different cellular programs that are stabilized through epigenetic mechanisms. The programs of stem cells seem more inclusive, and during the process of differentiation a larger number of genes are silenced than activated. The reactivation of pluripotency recovers of the stem cell program in terminally differentiated cells has been achieved experimentally. This process, called reprogramming, brings new hope for the development of a regenerative medicine with new capabilities for the treatment of chronic diseases, without the ethic restrains imposed by the use of embryonic cells.

Keywords : Stem cells; pluripotency; cellular reprogramming; transcription factors; Oct4; Sox2; Nanog; regenerative medicine.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License