SciELO - Scientific Electronic Library Online

 
vol.32 issue3Histomorphometric Evaluation of Soleus and Lateral Gastrocnemius Muscles of Animals Submitted to Pharmacological Manipulation with FluoxetineMorphometrical Analysis of the Effect of Nicotine Administration on Brain's Prefrontal Region in Male Rat author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google

Share


International Journal of Morphology

On-line version ISSN 0717-9502

Abstract

TANASOV, Valéria Simões et al. Use of Anabolic Steroid Altered the Liver Morphology of RatsEl Uso de Esteroides Anabólicos Altera la Morfología del Hígado de Ratas. Int. J. Morphol. [online]. 2014, vol.32, n.3, pp.756-760. ISSN 0717-9502.  http://dx.doi.org/10.4067/S0717-95022014000300002.

The aim of this research was to investigate the effect of testosterone propionate administration in the liver of rats. The rats were divided in the following groups: Initial control (SC), Aged control (SE) and Anabolic group (SA). Testosterone propionate was administered three times per week during 16 weeks. Using morphoquantitative techniques, we quantified the volume densities of lobular and non-lobular parenchyma, area and number of nuclei of hepatocytes. The data were analyzed statistically using mean and standard deviation, ANOVA one-way and level of significance about p0.05. Our results showed an increase in capillaries, perisinusoidal spaces and biliary ducts in SE group compared to SC. SA group showed a decrease in hepatic cells, non-lobular volume density and hepatocytes nuclei area, but also an increase in capillaries, perisinusoidal spaces, biliary ducts, number of hepatocytes and non-hepatocyte nuclei compared to SC. We conclude that a direct toxicity may have occurred, with consequent loss of the cells.

Keywords : Aging; Testosterone proprionate; Hepatic tissue; Animals.

        · abstract in Spanish     · text in English     · English ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License