SciELO - Scientific Electronic Library Online

 
vol.32 número4Anatomía Laparoscópica sin Gas y Biopsia Renal de los Riñones de la Yegua de PieEfecto de Tres Meses de un Programa de Ejercicio Acuático en la Composición Corporal de Adultas Mayores índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

Links relacionados

  • En proceso de indezaciónCitado por Google
  • No hay articulos similaresSimilares en SciELO
  • En proceso de indezaciónSimilares en Google

Compartir


International Journal of Morphology

versión On-line ISSN 0717-9502

Resumen

MELO, A et al. Hypermethylation of Tumor Suppressor Gene p53 in Chilean Pediatrics Patients Under 15 Years with Acute Lymphoblastic Leukemia. Int. J. Morphol. [online]. 2014, vol.32, n.4, pp.1243-1247. ISSN 0717-9502.  http://dx.doi.org/10.4067/S0717-95022014000400019.

Acute lymphoblastic leukemia (ALL) is the most common hematology oncology malignancy in pediatric patients counting up to 75% of leukemias and 32­35% of all childhood cancers. Although ALL is considered a disease with a genetic basis, it is increasingly clear that epigenetic alterations play a central role in the pathogenesis and work was to determine the methylation status in promoter-exon1 of the TSG-p53 and association with survival in children under 15 years with ALL. In our study 40 patients from the Araucanía Region, Chile were analyzed. Hypermethylation of p53 was determined by combining restriction enzymes sensitive to methylation (HpaII and EcoR II) and polymerase chain reaction. Results indicated that 15/40 cases (37.5%) showed hypermethylation. Statistical difference was found in survival according to p53 methylation status in the girls group (p=0.02). Considering all patients, there was a trend to improved survival when leukocyte counts were <30.000/ul (p=0.08). We found the p53 gene frequently hypermethylated in the promoter-exon1 region. This would indicate that TSG p53 hypermethylation may be an important event in the pathogenesis of ALL.

Palabras clave : Hypermethylation; p53 tumor suppressor gene; Acute lymphoblastic leukemia; Childhood leukemia; Survival.

        · resumen en Español     · texto en Español     · Español ( pdf )

 

Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons