SciELO - Scientific Electronic Library Online

 
vol.34 issue1Occurrence of the Accessory Foramina of the Mandibular Ramus in Brazilian Adults and its Relation to Important Mandibular LandmarksAnalysis of Terms Used in the Literature to Refer to Temporomandibular Joint Capsule and Joint Ligaments author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google

Share


International Journal of Morphology

On-line version ISSN 0717-9502

Abstract

ROA, Ignacio et al. Celecoxib/PLGA Suppresses Angiogenesis and Lung Metastasis of Murine Experimental Breast Cancer. Int. J. Morphol. [online]. 2016, vol.34, n.1, pp.335-341. ISSN 0717-9502.  http://dx.doi.org/10.4067/S0717-95022016000100048.

Angiogenesis and metastasis are critical events on the tumor invasion process. Their close association is related as a good target in antitumor therapy. The aim was to analyze lung metastasis pattern and angiogenesis following application of microencapsulated Celecoxib with poli(lactic-co-glycolic) acid in mice. An experimental tumor model was assessed, induced by TA3-MTX-R cells, in 18 mice, separated in 3 groups of 6 animals and treated with 2 intramuscular Celecoxib presentations (Group Control; Group Cx 1000 ppm and Group Cx 1000 ppm+PLGA). Mice were sacrificed and histologically processed to stain slides with H&E and Arteta Trichromic. The study revealed that the lung showed a significant heterogeneity, and a perivascular metastasis pattern; moreover, Celecoxib associated to poli(lactic-co-glycolic) acid reduces tumor invasion and pulmonary angiogenesis. The results are similar to partial previous descriptions and are comparable to other tumor lines, concluding that Celecoxib/poli(lactic-co-glycolic) acid is a potential candidate in antitumor therapy.

Keywords : Angiogenesis; Metastasis; Lung; Cancer; Celecoxib; PLGA.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License