SciELO - Scientific Electronic Library Online

vol.36 issue2Methotrexate Changes the Testicular Tyrosine Phosphorylated Protein Expression and Seminal Vesicle Epithelia of Adult RatsStereological Assessment of Nephroprotective Effects of Trachyspermum ammi Essential Oil against Carbon Tetrachloride-Induced Nephrotoxicity in Mice author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google


International Journal of Morphology

On-line version ISSN 0717-9502


MANTEROLA, Carlos et al. Development and Initial Validation of a Scale to Measure Methodological Quality in Diagnostic Accuracy Studies. The MInCir Proposal. Int. J. Morphol. [online]. 2018, vol.36, n.2, pp.743-749. ISSN 0717-9502.

Research in diagnostic accuracy studies (DAS) is a rapidly developing area in medicine, but there are only three instruments used in this scenario. The aim of this study was to design and validate a scale to determine methodological quality (MQ) of DAS. Scale validation study. A systematic literature review about the MQ of diagnostic accuracy studies was accomplished, and an expert panel generated a first draft (content validity) of the scale. An alphanumeric order was given and rated by six researchers (second draft) and a pilot study to optimise its use and understanding was performed (third draft). Two independent researchers applied the final scale (9 items/3 domains) to 110 articles from 13 journals with high, medium and low impact factors. Criterion validity was determined by contrasting MQ scores with the Oxford Centre for Evidence-Based Medicine levels of evidence. The construct validity of the extreme groups and high and low IF were estimated. The intraclass correlation coefficient was used to determine inter-observer reliability, and the cut-off point was calculated using a ROC curve. The best cut-off point was 24 points, with an under curve area of 93.4 %. The content validity rating was 80-100 % for all included items. Criterion and construct validity were statistically significant with p<0.05. Interobserver reliability was estimated in 0.96. A scale to measure the MQ of DAS was designed and validated.

Keywords : Diagnostic Techniques and Procedures; Validation Studies[Publication Type]; Reproducibility of Results; Weights and Measures; Evidence-Based Medicine.

        · abstract in Spanish     · text in English     · English ( pdf )