SciELO - Scientific Electronic Library Online

vol.36 número3Actividad Citotóxica del Extracto y la Fracción Activa de Turbinaria decurrens Bory en la Línea Celular de Cáncer de Colon HCT-116Expresión de Nestina, Factor de Transcripción SOX3 y Proteína Homeobox DLX-4 en el Tejido Facial de Niños con Fisura Labiopalatina índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados




Links relacionados

  • En proceso de indezaciónCitado por Google
  • No hay articulos similaresSimilares en SciELO
  • En proceso de indezaciónSimilares en Google


International Journal of Morphology

versión On-line ISSN 0717-9502


AL-HASHEM, Fahaid et al. Metformin Protects Against Thioacetamide Induced Liver injury in Rats. Int. J. Morphol. [online]. 2018, vol.36, n.3, pp.984-990. ISSN 0717-9502.

Potent heptatotoxic chemicals such as carbon tetrachloride and thioacetamide (TAA) are used to evaluate hepatoprotective agents. Here we sought to investigate the potential protective effect of the antidiabetic and antioxidant drug, metformin against liver injury induced by TAA. Model group rats received several injections of TAA (200 mg/kg) before being sacrificed after 10 weeks and the protective group started the treatment two weeks prior to TAA injections and continued receiving both agents, metformin and TAA until the end of the experiment, week 10. Harvested liver tissues were examined using light microscopy and liver homogenates were assayed for oxidative and anti-oxidative stress markers that are known to be modulated in liver injury. Profound damage in the hepatic tissue of the model group such as liver fibrosis and destruction of hepatic architectures were revealed, which were protected by metformin comparable to the control group. TAA augmented the oxidative stress biomarker, malondialdehyde (MDA) and ameliorated the antioxidant superoxide dismutase (SOD), which were significantly (p<0.05) protected by metformin treatment. These results indicate that metformin effectively protects against TAA-induced hepatotoxicity in a rat model.

Palabras clave : Liver fibrosis; Thioacetamide; Oxidative stress; Metformin; Rat model.

        · resumen en Español     · texto en Inglés     · Inglés ( pdf )