SciELO - Scientific Electronic Library Online

vol.37 issue1Antiangiogenic Effect of Triamcinolone Associated with Lidocaine with Epinephrine for Dental use in Chicken Chorioallantoic MembraneDoes Oregano Protect Against Testicular Toxicity Produced by Ethylene Glycol in Adult Male Albino Rat? author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google


International Journal of Morphology

On-line version ISSN 0717-9502


AL-KARIM, Saleh; RAMADAN, Wafaa S; ABDEL-HAMID, Ghada A  and  AL-QUDSI, Fatma. Does Neuroectodermal Stem Cells Transplantation Restore Neural Regeneration and Locomotor Functions in Compressed Spinal Cord Injury Rat Model?. Int. J. Morphol. [online]. 2019, vol.37, n.1, pp.349-357. ISSN 0717-9502.

The aim of this study was to determine the possible regenerative effect of neuroectodermal stem cells on the ultrastructural, and locomotor function resulting from compressed injury to the spinal cord in a rat model. Forty male rats were divided into control and sham groups (20 rats each). Compressed spinal cord injured (CSCI) were forty rats which subdivided equally into: untreated, treated by neuroectodermal stem cells (NESCs). After four weeks, all rats in different groups were scarified, samples were taken from central, cranial, and caudal to the site of spinal cord injury. Specimens were prepared for light and electron microscopic examination. The number of remyelinated axons in central, cranial and caudal regions to the injured spinal cord after transplantation of NESCs was counted. The open field test assessed the locomotor function. Results revealed that compressed spinal cord injury resulted in loss and degeneration of numerous nerve fibers, myelin splitting and degeneration of mitochondria. Four weeks after transplantation of NESCs regenerated axons were noticed in cranial and central sites, while degenerate axons were noticed caudal to the lesion. Number of remyelinated axons was significantly increased in both central and cranial to the site of spinal cord injury in comparison with caudal region which had the least number of remyelinated axons. Transplantation of NESCs improved significantly the locomotor functional activity In conclusion, neuroectodermal stem cells transplantation ameliorated the histopathological and ultrastructural changes, and improved the functional locomotor activity in CSCI rat.

Keywords : Neuroectodermal; Stem cells; Spinal cord; Injury; Regeneration; Rat.

        · abstract in Spanish     · text in English     · English ( pdf )