SciELO - Scientific Electronic Library Online

 
vol.37 issue4Hunter-Schreger Bands: Terminological Propose author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google

Share


International Journal of Morphology

On-line version ISSN 0717-9502

Abstract

CACERES, D. E et al. A Platform to Understand Amyotrophic Lateral Sclerosis (ALS) and Extend Human Motor Neurons Longevity. Int. J. Morphol. [online]. 2019, vol.37, n.4, pp.1203-1209. ISSN 0717-9502.  http://dx.doi.org/10.4067/S0717-95022019000401203.

In vitro modeling of neurodegenerative diseases is now possible by using patient-derived induced pluripotent stem cells (iPS). Through them, it is nowadays conceivable to obtain human neurons and glia, and study diseases cellular and molecular mechanisms, an attribute that was previously unavailable to any human condition. Amyotrophic lateral sclerosis (ALS) is one of the diseases that has gained a rapid advance with iPS technology. By differentiating motor neurons from iPS cells of ALS- patients, we are studying the mechanisms underlying ALS- disease onset and progression. Here, we introduce a cellular platform to help maintain longevity of ALS iPS-motor neurons, a cellular feature relevant for most late-onset human diseases. Long term cultures of patient-derived iPS cells might prove to be critical for the development of personalized-drugs.

Keywords : Motor neurons; Amyotrophic Lateral Sclerosis (ALS); Induced pluripotent stem cells (iPS); Glia.

        · abstract in Spanish     · text in English     · English ( pdf )