SciELO - Scientific Electronic Library Online

 
vol.38 número4Una Revisión Meta-Analítica para la Evaluación del Dimorfismo Sexual de la PatelaCambios Morfológicos en la Cara Media de Perros Beagle Tratados por Distracción Trans-Sutural índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

Links relacionados

  • En proceso de indezaciónCitado por Google
  • No hay articulos similaresSimilares en SciELO
  • En proceso de indezaciónSimilares en Google

Compartir


International Journal of Morphology

versión On-line ISSN 0717-9502

Resumen

MUREITHI, Pauline M; KAVOI, Boniface M; ONYANGO, Cecilia M  y  MATHIU, Mbaabu P. Antiulcerogenic Effects of Selected African Nightshades (Solanum nigrum Linn.) Genotypes on the Rat Stomach: A Morphologic and Morphometric Study. Int. J. Morphol. [online]. 2020, vol.38, n.4, pp.940-946. ISSN 0717-9502.  http://dx.doi.org/10.4067/S0717-95022020000400940.

Solanum nigrum (SLN), commonly known as African nightshade, is used as a vegetable as well as in the management and treatment of various ailments including gastric ulcers. We analyzed, both grossly and microscopically using H&E, Masson’s trichrome and PSA staining methods, the protective effects of aqueous leaf extracts of three Kenyan SLN genotypes namely S. scabrum (SSB), S. sarrachoides (SSR) and S. villosum (SVL) on ethanol-induced gastric lesions in rats. There was evidence of gastro-protection by all the three genotypes with the SSB showing the highest ulcer inhibition score (76.37 %) followed by SSR (72.51 %) and SVL (63.30 %). SLN-pretreated rats showed less areas of gastric mucosal surface erosion. Additionally in the pretreated animals, the depth of the ulcers were markedly reduced, reaching only the gastric pit region except in those treated with SVL where the ulcers penetrated slightly more deeply to affect the gastric glands. Compared with controls, the mean microscopic ulcer index decreased 5.07, 3.55 and 2.37-fold in rats pretreated with SSB, SSR and SVL extracts respectively. Results of this work show extracts of the three SLN genotypes to have antiulcerogenic potential but at varied strengths, thus confirming earlier reports that phytoconstituents and hence the efficacy of a medicinal plant may be influenced by genetic factors.

Palabras clave : Gastric ulcer; Inhibition; Kenyan; Solanum nigrum.

        · resumen en Español     · texto en Inglés     · Inglés ( pdf )