SciELO - Scientific Electronic Library Online

 
vol.51 issue4STUDY OF PHENOL PHOTODEGRADATION WITH TiO2/-WO3 COUPLED SEMICONDUCTORS ACTIVATED BY VISIBLE LIGHTCATALYTIC OXIDATION OF EMISSIONS IN COMBUSTION SYSTEMS FOR FOREST BIOMASS, USING CATALYSTS WITH TiO2 SUPPORT author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Journal of the Chilean Chemical Society

On-line version ISSN 0717-9707

Abstract

MARTINEZ, ROLANDO et al. SYNTHESIS AND CONFORMATIONAL ANALYSIS OF LEPTOCARPIN DERIVATIVES: INFLUENCE OF MODIFICATION OF THE OXIRANE RINGON LEPTOCARPIN'S CYTOTOXIC ACTIVITY. J. Chil. Chem. Soc. [online]. 2006, vol.51, n.4, pp.1010-1014. ISSN 0717-9707.  http://dx.doi.org/10.4067/S0717-97072006000400003.

The reaction in acidconditions of Leptocarpin 1, a compound with antitumor activity, formed two new isomeric products, 8b-angeloyl-1b,3b-dihydroxy-4,10-dimethyl,-D11(13) methylen-4Z,9Z-dieneheliangol-6,12-olide 2 and 8b-angeloyl-1b,3b-dihydroxy-4-methyl-D11(13),D11(14)-dimethylen-4Z-eneheliangol-6,12-olide 3, whose structures reported in this study were established by spectroscopy (1H-NMR, 13C-NMR, MS and IR) and confirmedthrough ROESY experiments and theoretical studies by molecular mechanics. The in vitro cytotoxicity of these isomeric compounds was less active than leptocarpin, showing the importance of the oxirane ring in the biological activity. Cytotoxic activity was measured in six cancer cell lines

Keywords : Conformational analysis; Heliangolide; Sesquiterpene lactones; Cytotoxicity.

        · text in English

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License