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vol.54 issue4THERMAL STABILITY AND KINETIC STUDIES OF COBALT (II), NICKEL (II), COPPER (II), CADMIUM (II) AND MERCURY (II) COMPLEXES DERIVED FROM N-SALICYLIDENE SCHIFF BASESA RP-HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF DILTIAZEM AND QUINOLONES IN BULK, FORMULATIONS AND HUMAN SERUM author indexsubject indexarticles search
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Journal of the Chilean Chemical Society

On-line version ISSN 0717-9707

Abstract

RAMAN, N; JOSEPH, J; SAKTHIVEL, A  and  JEYAMURUGAN, R. SYNTHESIS, STRUCTURAL CHARACTERIZATION AND ANTIMICROBIAL STUDIES OF NOVEL SCHIFF BASE COPPER(II) COMPLEXES. J. Chil. Chem. Soc. [online]. 2009, vol.54, n.4, pp.354-357. ISSN 0717-9707.  http://dx.doi.org/10.4067/S0717-97072009000400006.

Five novel copper(II) complexes have been synthesized using Schiff base ligands, synthesized by the condensation reaction of anthranilic acid and Knoevenagel β-ketoanilide condensates (obtained by the condensation of acetoacetanilide and substituted benzaldehydes). The ligands and copper(II) complexes have been characterized on the basis of Microanalytical, Mass, UV-Vis., IR, 'H NMR, ESR, XRD and CV spectral studies, as well as magnetic susceptibility and conductivity data. On the basis of spectral studies, a square-planar geometry has been proposed for the copper(II) complexes. From the XRD data, the CuL-1 complex has the crystallite size of 50 nm respectively. The in vitro antimicrobial activity of the compounds is tested against the bacteria Escherichia coli, Salmonella typhi, Staphylococcus aureus, Klebsiella pneumoniae and Pseudonomas aeruginosa and fungi Aspergillus niger, Rhizopus stolonifer, Aspergillus flavus, Rhizoctonia bataicola and Candida albicans by well diffusion method. The complexes show stronger antimicrobial activity than the free ligands. They represent a novel class of metal-based antimicrobial agents which provide opportunities for a large number of synthetic variations for modulation of the activities.

Keywords : Schiff base ligands; square-planar; Knoevenagel.

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