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Journal of the Chilean Chemical Society

On-line version ISSN 0717-9707

Abstract

SHAMSUZZAMAN; SHAHEEN KHAN, MOHD  and  ALAM, MAHBOOB. SYNTHESIS, CHARACTERIZATION AND ANTI-MICROBIAL ACTIVITY OF NEW STEROIDAL CHOLEST-5-EN-7-ONE DERIVATIVES FUSED WITH SUBSTITUTED PYRAZOLINE RING. J. Chil. Chem. Soc. [online]. 2009, vol.54, n.4, pp.372-374. ISSN 0717-9707.  http://dx.doi.org/10.4067/S0717-97072009000400010.

The reaction of cholest-5-en-7-one (1), its 3β-acetoxy (2) and 3β-chloro (3) analogues with thiosemicarbazide in sodium ethoxide affords 2'-thiocarbamoyl-cholest [5,7-cd] pyrazoline (4), 2'-thiocarbamoyl-3β-acetoxycholest [5,7-cd] pyrazoline (5), and 2'-thiocarbamoyl-3β-chloro cholest [5,7-cd] pyrazoline (6), respectively. The structures of the newly synthesized compounds have been established on the basis of physical, analytical and spectral data. Their antibacterial activities were tested in vitro by disk diffusion assay against Gram-positive and Gram-negative bacterial strains of bacteria.

Keywords : thiosemicarbazide; pyrazolines; cholest-5-en-7-one; thiocarbamoyl; anti-bacterial activity.

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