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vol.56 número1TEMPORAL VARIATION OF PAHS IN SOILS FROM THE BIOBÍO REGION: CENTRAL SOUTHERN CHILECHARACTERIZATION OF A NEW NEW Ag+ -SELECTIVE ELECTRODE BASED ON N3S5-THIAAZACROWN ETHER AS NEUTRAL IONOPHORE índice de autoresíndice de materiabúsqueda de artículos
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Journal of the Chilean Chemical Society

versión On-line ISSN 0717-9707

Resumen

ROGEL, CRISTIAN et al. FORMULATION AND CHARACTERIZATION OF INCLUSION COMPLEXES USING HYDROXYPROPYL-β-CYCLODEXTRIN AND FLORFENICOL WITH CHITOSAN MICROPARTICLES. J. Chil. Chem. Soc. [online]. 2011, vol.56, n.1, pp.574-578. ISSN 0717-9707.  http://dx.doi.org/10.4067/S0717-97072011000100011.

The interaction between Florfenicol (FF), Hydroxypropyl-β-cyclodextrin (HPβCD), and Chitosan (CH) has been studied in aqueous solution and in solid state, using 3 preparation methods (Evaporation, Lyophilization, Spray Drying) for HPβCD and only Spray Drying for Chitosan. The phase solubility study shows that the complex is formed with 1:1 stoichiometry and 181,4 M1 as the association constant. The analysis with Differential Scanning Calorimetry (DSC) together with Scanning Electron Microscopy (SEM) micrographs evidenced the formation of inclusion complexes, mainly with the product prepared by spray drying. Studies in vitro showed that FF solubility was improved almost to double, with a better dissolution profile exhibited by the product prepared by spray drying.

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