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vol.56 número4REGIOSELECTIVE AND HIGH-YIELDING BROMINATION OF PHENOLS AND ANILINS USING N-BROMOSACCHARIN AND AMBERLYST-15INVESTIGATION INTO THE REGIOCHEMISTRY OF SOME PYRAZOLES DERIVED FROM 1, 3-DIPOLAR CYCLOADDITION OF ACRYLONITRILE WITH SOME NITRILIMINES: THEORETICAL AND EXPERIMENTAL STUDIES índice de autoresíndice de assuntospesquisa de artigos
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Journal of the Chilean Chemical Society

versão On-line ISSN 0717-9707

Resumo

PESSOA-MAHANA, HERNÁN et al. SYNTHESIS OF 1-BENZYL-3-[4-(ARYL-1-PIPERAZINYL) CARBONYL]-1H-INDOLES: NOVEL LIGANDS WITH POTENTIAL D4 DOPAMINERGIC ACTIVITY. J. Chil. Chem. Soc. [online]. 2011, vol.56, n.4, pp.866-869. ISSN 0717-9707.  http://dx.doi.org/10.4067/S0717-97072011000400009.

The synthesis of a series of functionalized 1-Benzyl-3-[4-Aryl-1-piperazingl]carbonyl-1H-Indoles 6(a-f), as a potential new class of bioactive ligands at D4 receptors is reported. The synthetic strategy took place through a five steps sequence to provide indole amides 6(a-f) in 75-92% yield.

Palavras-chave : Indole; Arylpiperazines; dopaminergic activity.

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