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vol.56 número4CERIMETRIC DETERMINATION OF FOUR ANTIHYPERTENSIVE DRUGS IN PHARMACEUTICAL PREPARATIONSHIGHLY EFFICIENT AND VERSATILE ACETYLATION OF ALCOHOLS, PHENOLS AND AMINES CATALYZED BY METHYLENEDIPHOSPHONIC ACID (MDP) UNDER SOLVENT-FREE CONDITIONS índice de autoresíndice de assuntospesquisa de artigos
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Journal of the Chilean Chemical Society

versão On-line ISSN 0717-9707

Resumo

MUNAWAR HAYAT, M et al. HPLC DETERMINATION OF ETOPOSIDE IN INJECTABLE DOSAGE FORMS. J. Chil. Chem. Soc. [online]. 2011, vol.56, n.4, pp.881-883. ISSN 0717-9707.  http://dx.doi.org/10.4067/S0717-97072011000400012.

1. The present study describes a direct and an alternative HPLC method for the determination of etoposide in injectable dosage forms. Etoposide, an antineoplastic drug, was eluted through C18 ODS Hypersil column of 250 ÷ 4.6 mm id with 5 ìçé particle size using simple mobile phase of methanol: water (1:1, v/v) at a flow rate of 1.0 mL min1 and detected at 204 nm. The limit of detection of etoposide was 0.03 µg mL-1. The proposed method was found linear in the range of 0.25 µg mL1 to 62.5 µg mL1 and CV was 1.3% at 0.25 µg mL1 , 0.48% at 3.90 µg mL1 and 0.13% at 62.5 µg mL1. The accuracy of the developed method for two injectable dosage forms was 99.4 and 99.7% with RSD of 0.3%. The validation results and statistical data demonstrate that the method is simple, cost effective, reproducible and suitable in quality analysis of the active ingredient and dosage form.

Palavras-chave : Etoposide; HPLC; injectable dosage forms; nefopam.

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