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vol.56 número4STUDY OF THERMODYNAMIC AND NMR PROPERTIES OF SOME CYCLOHEXANE DERIVATIVESSYNTHESIS AND EVALUATION OF 5-(6-METHOXYNAPHTHALEN-2-YL)-1-ARYL-1-(4-(TRIFLUOROMETHYL)PHENYLAMINO)PENTAN-3-ONE AS POTENTIAL ANTIDIABETIC AGENTS índice de autoresíndice de assuntospesquisa de artigos
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Journal of the Chilean Chemical Society

versão On-line ISSN 0717-9707

Resumo

CHENNAIAH, M; VEERAIAH, T; CHARAN SINGH, T  e  VENKATESHWARLU, G. EXTRACTIVE SPECTROPHOTOMETRY METHODS FOR DETERMINATION OF RASAGILINE MESYLATE IN PHARMACEUTICAL FORMULATIONS USING ACIDIC TRIPHENYLMETHANE DYES. J. Chil. Chem. Soc. [online]. 2011, vol.56, n.4, pp.926-929. ISSN 0717-9707.  http://dx.doi.org/10.4067/S0717-97072011000400022.

Three simple and sensitive extractive spectrophotometric methods have been described for the assay of Rasagiline mesylate either in pure form or in pharmaceutical formulations. The developed methods involve formation of coloured chloroform extractable ion-pair complexes of the drug with bromothymol blue (BTB), bromophenol blue (BPB) and bromocresol green (BCG) in acidic medium. The extracted complexes showed absorbance maxima at 414 nm for all three methods. Beer's law is obeyed in the concentration ranges 3.0-30, 3.0.0-30 and 2.0-25µg/ml with BTB, BPB and BCG respectively. The effect of concentration of dye, pH, and interference of excipients have been studied and optimized. The limits of detection and quantification have been determined for three methods. All the three methods have been validated as per the guidelines of ICH. The methods have been applied to the determination of drug in commercial tablets and results of analysis were validated statistically through recovery studies.

Palavras-chave : Rasagiline mesylate; Bromothymol blue; Bromophenol blue; Bromocresol green; Spectrophotometry.

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