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Journal of the Chilean Chemical Society

versão On-line ISSN 0717-9707

Resumo

TORRES, PABLO et al. PREPARATION AND CHARACTERIZATION OF THE EMAMECTIN BENZOATE/HYDROXYPROPYL-B-CYCLODEXTRIN INCLUSION COMPLEX. J. Chil. Chem. Soc. [online]. 2011, vol.56, n.4, pp.951-954. ISSN 0717-9707.  http://dx.doi.org/10.4067/S0717-97072011000400029.

The objective of this study was to prepare an inclusion complex of the insecticide emamectin benzoate (EB) with hydroxypropyl-β-cyclodextrin (HO-β-CD) by co-evaporation and spray drying methods. The complexation of both compounds was evaluated on the aqueous and solid state using phase solubility diagrams, differential scanning calorimetry (DSC), X-Ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). The aqueous solubility of the inclusion complexes at pH 8 had a 2-fold increase respect to the drug alone and dissolution profiles showed a rise in the dissolution rate. These results suggest that the use of HO-β-CD could be an interesting alternative to enhance the bioavailability of EB in salmons.

Palavras-chave : Emamectin benzoate; cyclodextrin; inclusion complex; salmon.

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