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vol.57 número2TRIMETHYLSILYL CHLORIDE CATALYZED SYNTHESIS OF SUBSTITUTED BENZIMIDAZOLES USING TWO PHASE SYSTEM UNDER MICROWAVE CONDITIONS, AND THEIR ANTIMICROBIAL STUDIESKINETIC STUDY OF CHARGE TRANSFER COMPLEXES OF IODINE WITH SOME CROWN ETHERS IN NONAQUEOUS SOLVENTS índice de autoresíndice de assuntospesquisa de artigos
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Journal of the Chilean Chemical Society

versão On-line ISSN 0717-9707

Resumo

CANETE, A et al. BIOLOGICAL ACTIVITIES AND CORRELATIONS TENDENCY OF ELECTROCHEMICAL PROPERTIES OF SOME INDOLIZINO[1,2-B]QUINOLINE DERIVATIVES. J. Chil. Chem. Soc. [online]. 2012, vol.57, n.2, pp.1126-1129. ISSN 0717-9707.  http://dx.doi.org/10.4067/S0717-97072012000200015.

We report the preparation of a series of indolylquinone and pyridine derivatives in order to evaluate structure-activity relationships in human gastric (AGS), lung (SK-MES-1), bladder (J82) cancer cell lines and human normal lung fibroblasts (MCR-5). Two correlations tendency between half-wave redox potentials against their antineoplasic activity were found making it possible to establish that for epithelial human gastric cancer (AGS) cell lines and human normal lung fibroblasts (MCR-5). The quinone bioreduction should correspond to a one electron process under normomix conditions, whilst for all other lines this process should correspond to a two electron attachment via a hypoxic process.

Palavras-chave : Quinone; Electrochemical properties; Antiproliferative activity.

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