Resumen

ANACONA, J.R; BRAVO, ALINA  y  LOPEZ, MARIA E. CEFOPERAZONE METAL COMPLEXES: SYNTHESIS AND CHARACTERIZATION. J. Chil. Chem. Soc. [online]. 2013, vol.58, n.1, pp.1520-1523. ISSN 0717-9707.  http://dx.doi.org/10.4067/S0717-97072013000100004.

Cefoperazone (Hcefopz) interacts with transition metal(II) ions to give [M(cefopz)Cl] complexes (M = Fe, Co, Ni, Cu and Cd) and [Fe(cefopz)Cl]Cl which were characterized by physicochemical and spectroscopic methods. The spectra indicated that the antibiotics act as monoanionic multidentate NO₃ chelating agent towards metal ions, via the amides, and carboxylate and N-azomoiety. The complexes are non-toxic, insoluble in water and common organic solvents and probably have polymeric structures.

Palabras clave : cefoperazone sodium; antibiotic; metal complexes; antibacterial activity.

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