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vol.58 número2COMPARATIVE STUDY BETWEEN N,N'-BIS (ACETYLACETONE)-O-PHENYLENEDIAMINE AND (MONOACETYLACETONE)-O-PHENYLENEDIAMINE SCHIFF BASE COMPLEXESA STABILITY- INDICATING HPTLC METHOD FOR QUANTIFICATION OF ENALAPRIL MALEATE IN TABLETS índice de autoresíndice de materiabúsqueda de artículos
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Journal of the Chilean Chemical Society

versión On-line ISSN 0717-9707

Resumen

BRAVO, FELIPE et al. FORENSIC CASES IN THE NORTH OF CHILE: DETERMINATION OF ANTIDEPRESSANT DRUGS IN HUMAN WHOLE BLOOD. J. Chil. Chem. Soc. [online]. 2013, vol.58, n.2, pp.1733-1736. ISSN 0717-9707.  http://dx.doi.org/10.4067/S0717-97072013000200020.

The consumption of antidepressant drugs has increased in these last years, leading to severe and lethal poisonings. In this work, analytical tools, namely GC/MSD and GC/NPD µECD, were used to identify and quantify several antidepressant drugs including amitriptyline, imipramine, sertraline, fluoxetine, and citalopram in forensic cases in the North of Chile during 2008-2011. Drugs were analyzed in biological arrays like blood. A solid phase extraction by Bond Elut Certify columns was applied in all these processes. Fluoxetine and sertraline were derivatized with pentafluoropropionic anhydride. Prazepam was used as internal standard (IS). The limit of detection (LOD) in blood were 0.5 - 20.07 ng/mL. The average extraction rate was 89.39% in blood. The relative standard deviation (RSD) was less than 3.6%, while the intra-day accuracy was < 5.5% and the inter-day was < 2.4%, referred to RSD. The procedures we have developed allow the quantification of drugs even at low therapeutic doses, a very important issue taking into account the nature of the analyzed arrays.

Palabras clave : antidepressants; gas chromatography; mass selective detector; ì-electron capture detector; solid-phase extraction.

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